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permanent residents... will be denied entry into the United States,” Health Secretary Alex Azar said.

Australia said it was barring entry to non-citizens arriving from China, while Australian citizens who had travelled there would be required to go into “self-isolation” for two weeks.

Vietnam suspended all flights from mainland China and Hong Kong effective from Saturday. Taiwan also initially appeared on the list of banned routes but references to the self-ruled island were later removed.

Similar expansive restrictions have been announced by countries including Italy, Singapore, and China’s northern neighbour Mongolia.

The United States, Japan, Britain, Germany and other nations had already advised their citizens not to travel to China.

Britain yesterday said it was temporarily withdrawing some diplomatic staff and their families from across the country, a day after the US State Department ordered embassy employees to send home family members under the age of 21.

Beijing insists it can contain the virus and called Washington’s advice against travel to China “unkind”.

“Certainly it is not a gesture of goodwill,” foreign ministry spokeswoman Hua Chunying said.

The US emergency declaration also requires Americans returning from the ground zero Chinese province of Hubei to be placed in mandatory 14-day quarantine, and health screening for American citizens coming from other parts of China.

The virus emerged in early December and has been traced to a market in Hubei’s capital Wuhan that sold wild animals.

It spread globally on the wings of a Lunar New Year holiday rush that sees hundreds of millions of Chinese people travel domestically and overseas.

In a bid to stop the contagion, the government has extended the holiday through this weekend and urged people to avoid public gatherings.

Many provinces and cities have called on companies to remain closed for another week after the holiday ends on Monday.

The economic fallout continued Saturday as Apple announced that “out of an abundance of caution” its China stores would be closed until February 9.

With public anger mounting in China, Wuhan’s top official admitted late Friday that authorities there had acted too slowly.

“If strict control measures had been taken earlier the result would have been better than now,” said Ma Guoqiang, the Communist Party chief for Wuhan.

Wuhan officials have been criticised online for withholding information about the outbreak until late December despite knowing of it weeks earlier.

China finally lurched into action last week, effectively quarantining whole cities in Hubei and tens of millions of people.

Unprecedented safeguards imposed nationwide include postponing the return to school, cutting bus and train routes, and tightening health screening on travellers nationwide.

But the toll keeps mounting at an ever-increasing pace, with health authorities on Saturday saying 46 more people had died in the preceding 24 hours, all but one in Hubei.

Another 2,102 new infections were also confirmed, bringing the total to nearly 12,000 -- far higher than the Severe Acute Respiratory Syndrome outbreak of 2002-03.

SARS, which is caused by a pathogen similar to the new coronavirus and also originated in China, killed 774 people worldwide -- most of them in mainland China and Hong Kong.

However, a team led by Gabriel Leung from the University of Hong Kong reported in The Lancet that More than 75,000 people have been infected with the coronavirus in Wuhan, ground zero of a global health emergency.