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'Holy grail' of insulin pill could end shot

Independent.co.uk
An insulin pill which could prove to be the “holy grail" of diabetes treatment has been developed by scientists.
Researchers have created a pill which could dramatically transform the way diabetics keep their blood sugar levels in check.
It is hoped the oral delivery of insulin could eliminate the need for painful injections, which up to 40 million people living with type 1 diabetes require once or twice a day.
In research published in the journal Proceedings of the National Academy of Sciences, researchers at the Harvard John A Paulson School of Engineering and Applied Sciences (SEAS) outlined how they found a way to deliver insulin orally. They said the pill could also mitigate many of the disease's life-threatening side effects that result from patients avoiding insulin therapy, which is administered from an injection under the skin or delivered by an insulin pump.
“But many people fail to adhere to that regimen due to pain, phobia of needles, and the interference with normal activities," said Samir Mitragotri and Hansjorg Wyss, two of the report's authors. "The consequences of the resulting poor glycemic control can lead to serious health complications."
Scientists have previously struggled to deliver insulin orally due to the fact it does not fare well when it encounters acids in the stomach and is poorly absorbed out of the intestine.
“Once ingested, insulin must navigate a challenging obstacle course before it can be effectively absorbed into the bloodstream," said Mitragotri.
"Our approach is like a Swiss army knife, where one pill has tools for
addressing each of the obstacles that are encountered."
To resist the breakdown of the insulin by gastric acid in the gut, the researchers used a capsule with an acid-resistant coating. When the coating reaches a more alkaline environment in the small intestine, it dissolves, releasing the insulin.
The insulin itself is carried in an ionic liquid comprised of choline (a vitamin-like essential nutrient) and geranic acid (a chemical which occurs naturally in cardamom and lemongrass and is widely used as a food additive), which can break through the layer of music lining the intestine and navigate the tight cell junctions of the intestine walls.
According to the researchers, the resulting formulation is biocompatible, easy to manufacture and can be stored for up to two months at room temperature without degrading - longer than some injectable insulin products currently on the market.