A week of violence between Israelis and Palestinians spread to the Gaza Strip yesterday, with Israeli troops killing five people in clashes on the border and Islamist movement Hamas calling for more unrest.

A fresh wave of stabbings also hit Israel and the West Bank, including a revenge attack by a Jewish suspect that wounded two Palestinians and two Arab Israelis.

The Gaza Strip had been mainly calm as unrest has shaken annexed east Jerusalem and the occupied West Bank in recent days.

But clashes broke out yesterday east of Gaza City

and Khan Yunis along the border with the Jewish state, with Israeli forces opening fire and killing four Palestinians and wounding 21, according to medics.

Ahmed al-Hirbawi, Shadi Dawla and Abed al-Wahidi, all aged 20, were killed when soldiers responded after youths threw stones at them on the Israel side of their common border. The fourth victim was Mohammed al-Raqab, 15.

An unnamed 19-year-old youth was killed east of Khan Yunis, in Gaza's south.

An army spokeswoman said about 200 Palestinians had approached the fence while hurling rocks and rolling burning tyres toward security forces. "Forces on the site responded with fire toward the main instigators to prevent their progress and disperse the riot," she said.

The spokeswoman confirmed "five hits” without elaborating.

The clashes came as Hamas's chief in Gaza called the spreading violence an intifada, or uprising, and urged further unrest.

In a sermon for weekly Muslim prayers at a mosque in Gaza City, Ismail Haniyeh said "we are calling for the strengthening and increasing of the intifada. ”

"ft is the only path that will lead to liberation," he said. "Gaza will fulfil its role in the Jerusalem intifada and it is more than ready for confrontation."

Stabbing attacks in the West Bank, Jerusalem and Israel itself along with rioting have raised fears of a third Palestinian intifada, following a first that began in 1987 and a second in 2000.

Hamas rules Gaza, squeezed between Egypt and Israel and separated from the West Bank, ft remains deeply divided from Palestinian president Mahmud Abbas's Fatah party.

The enclave has been hit by three wars with Israel since 2008. A 50-day conflict between Palestinian militants in Gaza and Israel summer 2014 left more than 2,200 people dead and 100,000 homeless.

Yesterday’s stabbings included one by a 17-year-old Jew in the southern Israeli city of Dimona that lightly or moderately wounded two Palestinians and two Arab Israelis.

The teen was arrested and told police he acted because "allArabsareterrorists."

The incident marked the first such attack against Palestinians after multiple stabbings that have targeted Jews since Saturday, killing two of them.

Israeli Prime Minister Benjamin Netanyahu quickly condemned the attack by the Jewish youth, a sign of concerns it could trigger further violence.

Attacks also continued against Israelis and Jews, with a Palestinian stabbing and lightly wounding a policeman near a West Bank settlement before being shot dead by the victim.

A Jewish 16-year-old was slightly hurt in a stabbing in Jerusalem by an 18-year-old Palestinian suspect, who was arrested.

And a woman was shot and wounded when she tried to stab a security guard at a bus station in the northern Israeli town of Afula, police said.

There have been 13 stabbing attacks since Saturday, including the revenge assault. Five of the alleged attackers have been killed.

Yesterday's escalation came as Israeli security forces sought to prevent the further spread of Palestinian unrest, with Netanyahu saying Thursday night the country faced a mostly unorganised "wave of terror".