Andy Murray crashed out of the US Open in the fourth round Monday, his earliest Grand Slam exit in five years, while 17-time major winner Roger Federer advanced to the quarterfinals.

South African 15th seed Kevin Anderson stunned British third seed Murray 7-6 (7/5), 6-3, 6-7 (2/7), 7-6 (7/0) to end his run of 18 consecutive major quarterfinals since the 2010 US Open.

"That's something that is disappointing to lose because of that. That's many years' work that's gone into building that sort of consistency. To lose that is tough, "said Murray.

"Also to lose a match like that, that was over four hours, tough after a couple of tough matches earlier in the tournament as well, it's a hard one to lose, for sure."

Anderson reached his first Grand Slam quarterfinal after seven prior fourth-round defeats.

"It was the match of my life," Anderson said. "This is a great accomplishment forme.' Anderson, who won his third career title two weeks ago at Winston-Salem, is the first South African in New York's last-eight since Wayne Ferreira in 1992.

"I'm just so excited to be through," said Anderson." Beating a guy like Andy, I really feel like I've taken a step forward. It's amazing. I feel like it's a great accomplishment."

Anderson, 1-5 in prior matches against Murray, fired 25 aces in ending an 0-15 career hoodoo against top-10 opponents to book a last-eight date with Swiss fifth seed Stan Wawrinka.

With New York City FC and former

England midfielder Frank Lampard watching from the player's box, Murray fell behind two sets and a break, roared back, but ultimately could not win the tension-packed encounter at Louis Armstrong Stadium.

Murray, the 2012 champion, had 49 winners and 20 unforced errors, but did not make a forehand winner until the last game of the second set. Anderson blasted 81 winners to 5 7 unforced errors.

Swiss second seed Federer, seeking his sixth US Open title, dispatched US 13th seed John Isner 7-6 (7/0), 7-6 (8/6), 7-5 to reach a quarterfinal against French 12th seed Richard Gasquet, who ousted Czech sixth seed Tomas Berdych 2-6, 6-3,6-4,6-1.

"Of course Roger will be the favourite of the match but I will have nothing to lose," said Gasquet, who is 2-14 lifetime against the Swiss star.

Federer, trying to become at 34 the oldest US Open champion since Ken Rosewall in 1970, stretched his US Open win streak over Americans to 12 since losing to Andre Agassi in 2001.

Isner had held in 110 consecutive US Open service games since broken by Germany's Philipp Kohlschreiber in the third round in 2013, but Federer ended that streak on match point to close out the victory in two hours and 3 9 minutes.

"John has one of the best serves in the game," Federer said. "You have just got to hang around and win your service games."

Federer also inflicted the first shutout tiebreak loss upon Isner.

"I served very well, picked up his second serves," Federer said. "You've got to get a little lucky."